In September of 2024, the FDA approved Ebglyss™ (lebrikizumab-lbkz manufactured by Eli Lily and Company) as a prescription treatment for moderate to severe eczema (atopic dermatitis). The medication had been previously approved in Europe and Japan.
What is Ebglyss™ and How Does It Work?
Lebrikizumab is a biologic interleukin (IL)-13 inhibitor. Ebglyss™ is recommended by the manufacturer for those with eczema that is not well controlled with topical prescription therapies, or those who cannot use topical therapies. It can be prescribed for adults or children 12 years old and older who weigh at least 88 pounds.
Initially, patients receive a starting dose of 500 mg., (two injections at weeks 0 and 2), then one injection of 250 mg every two weeks until the 16th week, or when the patient achieves adequate clinical results. The maintenance dose is a single monthly injection of 250 mg.
Advantages of Ebglyss™
In qualifying research studies, 38% of patients who took lebrikizumab achieved clear or almost clear skin at week 16 versus 12% who took a placebo. 10% saw results as early as 4 weeks. Of these patients, 77% maintained clear or almost clear skin at 1 year with once-monthly injections. Interestingly, 48% of patients who switched from lebrikizumab to placebo at week 16 maintained clear or almost clear skin at 1 year.
Drawbacks of Ebglyss™
Ebglyss™ may be unaffordable for many. At the time of FDA approval, information given to physicians shows that the wholesale price of each 250 mg. injection will be $3500. Patient costs will depend on their insurance coverage and participation in incentive programs that may be offered by the manufacturer or distributors.
Since Lebrikizumab is an interleukin (IL)-13 inhibitor, which is an immunosuppressant,
there are several possible side effects for those taking Ebglyss™, including: allergic reactions, eye problems, eye and eyelid inflammation, injection site reactions, shingles (herpes zoster).
If you have any of the following conditions, you should tell your doctor before taking Ebglyss™, as there may be contraindications: have parasitic infections, are scheduled to receive a ”live” vaccination, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed.
Our Recommendation: Use Caution and Conservatism
With any chronic health condition, a conservative care approach is best. What does that mean? It means working with your healthcare professional to find the root cause of your condition and then treating it with interventions that are the least intrusive, and least damaging, but still provide the best results. More invasive and risky treatments, like high-risk pharmaceutical treatments, should only be contemplated when all other treatments have failed and only after all pros and cons have been carefully considered.
Unfortunately, for many patients with skin conditions, the available choices of prescription drugs often fail the conservative care test. Their side effects can be extreme, compromising your health in other areas. They can be cost-prohibitive, even with insurance. Worst of all, they typically manage or mask the symptoms of eczema, TSW, acne, or psoriasis versus treating the root cause. This means you will likely need to use these pharmaceuticals continuously.
So, if you have tried everything to no avail and find yourself at the crossroads on whether or not to embark on a new drug therapy, we offer one other alternative to consider that is safer: Traditional Chinese Medicine (TCM) herbal medicine.
What TCM Can Do
TCM not only reduces the symptoms of eczema for many patients, but it also treats the root cause and brings the whole health of patients back into balance so they can experience their healthy natural skin again. It has no negative side effects and provides results that last even after cessation of treatment, with no withdrawal symptoms.
Positive Side Effects with TCM?
The “side effects” of herbal medicine are actually very positive. Herbal medicine dermatology patients report that other health issues (insomnia, digestion, allergies, PMS, and more) have concurrently improved with treatment. This is because when we take into consideration every system that contributes to the skin, instead of just focusing on the surface skin symptom, we treat the whole body. Therefore, it makes sense that other body functions would improve as well.
The other positive aspect of herbal medicine treatment is that its goal is returning the skin to normal function so that you can stop all treatment and maintain your healthy natural skin without assistance. TCM is interested in condition resolution, not symptom management.
Protect Your Long-Term Health
If you’ve struggled with eczema for a long time, it can be tempting to reach for anything that promises instant relief. However, your long-term health and well-being are priceless beyond measure. You owe it to yourself to consult with more than one professional before embarking on a high-risk pharmaceutical therapy if your life is not at stake.
And if you are currently on any prescription drugs to manage your skin and are wondering if it’s the right long-term solution for you, know that it’s possible to wean off your prescription therapy safely, and substitute more natural therapies that may deliver similar or even better results.
There are lots of choices, and every day there are more! We hope that sharing the facts about new eczema drugs will help you make a choice that is best for you on every level.
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About the Author
Olivia Hsu Friedman, LAc, Dipl.OM, DACM, Cert. TCMDerm, is the owner of Amethyst Holistic Skin Solutions and treats Acne, Eczema, Psoriasis, and TSW. Olivia treats patients via video conferencing using only herbal medicine. Olivia is Chair of the Board of Directors of the American Society of Acupuncturists, serves on the Advisory Board of LearnSkin, and is a faculty member of the Chicago Integrative Eczema Group sponsored by the National Eczema Association.